*Gil Gerard as Capt. William "Buck" Rogers
- Erin Gray as Col. Wilma Deering
- Thom Christopher as Hawk
- Jay Garner as Admiral Efram Asimov
- Wilfrid Hyde-White as Dr. Goodfellow
- Amanda Wyss as Laura
- Felix Silla as Twiki
- Mel Blanc as Voice of Twiki
- Sandy Champion as Chief Petty Officer Hall
- Alex Hyde-White as Lieutenant Martin
- James R. Parkes as Kovick
- Gary Bolen as Johnson
- Leigh C. Kim as Petrie
- Hubie Kerns Jr. as Mummy Monster
- Jeff David as Voice of Crichton (uncredited)